SPIKENET: An Evidence-Based Therapy for Long COVID

SPIKENET: An Evidence-Based Therapy for Long COVID

Blog Article

The COVID-19 pandemic has been one of the most impactful events in our lifetime, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).Multiple SARS-CoV-2 variants were reported globally, and a wide range of symptoms existed.Individuals who contract COVID-19 continue to suffer for a long time, known as long COVID or post-acute sequelae of COVID-19 (PASC).While COVID-19 pentair hose vaccines were widely deployed, both unvaccinated and vaccinated individuals experienced long-term complications.

To date, there are no treatments to eradicate long COVID.We recently conceived a new approach to treat COVID in which a 15-amino-acid synthetic peptide (SPIKENET, SPK) is targeted to the ACE2 receptor binding domain of SARS-CoV-2, which prevents the virus from attaching to the host.We also found that SPK precludes the binding of spike glycoproteins with the receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) of a coronavirus, murine hepatitis virus-1 (MHV-1), and with all SARS-CoV-2 variants.Further, SPK reversed the development of severe inflammation, oxidative stress, tissue edema, and animal death post-MHV-1 infection in mice.

SPK il barone wine also protects against multiple organ damage in acute and long-term post-MHV-1 infection.Our findings collectively suggest a potential therapeutic benefit of SPK for treating COVID-19.